PRODUCT
Summary
Mucin 4, a membrane-bound mucin, is the human homolog of the rat sialomucin complex (SMC). The Mucin 4 gene is the predominant mucin gene expressed in the normal urothelium and is also expressed in several normal tissues such as trachea, lung and testis. Dysregulation of mucin 4results in high levels of expression in pancreatic tumors and tumor cell lines. Induction of mucin 4 in pancreatic carcinoma by alltrans-retinoic acid is mediated through the retinoic acid receptor-å signaling pathway. MUC-4 is a very specific (100%) andsensitive (90%) marker of lung adenocarcinomas and is negative for mesotheliomas. MUC4 is expressed in many human adenocarcinomas. It is specifically expressed in lowgrade fibromyxoid sarcoma. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Colon
PROPERTIES
Form
Liquid
Buffer
Tris‐HCl buffer, 0.2% BSA
Preservative
0.09% sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fragment (around aa 1730-1864) of human MUC4 prote
Purification
Purified IgG
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
mucin 4, cell surface associated , ASGP , HSA276359 , MUC-4
Cellular Localization
Membrane , Secreted
Background
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]
Database
Research Area
REFERENCE
There are currently no references for Mucin 4 antibody [ZR201] (GTX03684). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Mucin 4 antibody [ZR201] (GTX03684). Be the first to share your experience with this product.
